Your neighborhood pharmacy since 1848.
Four generations on Canal Street. Familiar faces, practical help with your medications, and a new private room for walk-in vaccines. Not a chain.

Established 1848
Four generations of serving Ellenville from Canal Street.
Locally owned
Owned by Dr. Laura Villegas, Dr. Paul Sommer and Daniel Matthews.
Walk-in vaccines
Six vaccines, no appointment, given behind a closed door.
One-call transfers
Call us. We handle the paperwork with your old pharmacy.

New at Matthews
Our private vaccination room
Private enough to ask whatever you want to ask.
Every vaccination happens in our new private vaccination room: a dedicated space for vaccinations and consultations, comfortable and confidential, away from the sales floor. Walk in; no appointment needed.
- FluAges 6 and up
- COVID-19Ages 18 and up
- RSVAges 18 and up
- PneumoniaAges 18 and up
- ShinglesAges 18 and up
- TdapAges 18 and up
No doctor’s office visit needed. We do not offer travel vaccines.
What we do
Practical help, from the counter to your door.
- ImmunizationsFlu, COVID-19, RSV, pneumonia, shingles and Tdap. Walk in, no appointment.
- Private Vaccination RoomA dedicated, confidential room for vaccinations and consultations, away from the sales floor.
- Medication PackagingHelp keeping track: a month of medications sorted into dated, easy-open packets.
- DeliveryVillage and out-of-village delivery, plus no-charge Mon/Thu delivery for local senior housing residents and med sync patients.
- Medication SynchronizationLine up your refills so they are ready together. Sync patients qualify for no-charge Mon/Thu delivery.
- Durable Medical EquipmentCanes, walkers, home safety items, and specialized equipment ordered for next day.
- Pharmacist ConsultationsSlow down, ask questions, and understand your medications, privately.
- Medicare Open EnrollmentOne-on-one plan reviews, October 15 – December 7.
- Chronic Care ManagementSteady support with regular check-ins and medication reviews.
Help keeping track of medications
No pill organizer to refill on a Sunday night.
We sort a month of your medications into dated, easy-to-open packets, so there is no wondering whether the morning dose was taken.
- Self-pay
- $15 / month
- Through Medicare
- Certain plans may cover packaging and delivery. You may qualify; call and we will check.
- 1
A month, sorted
We sort a month of your medications into packets.
- 2
Dated and easy to open
Each packet is dated, so you can see at a glance what is next and what was already taken.
- 3
One call about coverage
Some patients in certain Medicare plans may qualify for packaging and delivery as long-term care at home. Requirements vary, so call and we will check.
Delivery
Brought to your door, priced plainly.
What delivery costs depends on where you live and whether you are part of one of our no-charge routes.
| Who | When | Cost |
|---|---|---|
| Residents of local senior housing, and medication synchronization patients | Mondays & Thursdays | No charge |
| Within the village | Monday – Friday | $3 |
| Outside the village | Call for days | $7 |
Not sure which applies? Call (845) 647-6222.



The people behind the counter
Laura started here stickering orders. Now she runs the place.
Dr. Laura Villegas got her first job at Matthews cleaning shelves. Dr. Paul Sommer came back every summer break while earning his PharmD. Daniel Matthews is the fourth generation of the family that started it all.
We sponsor Little League and the Blueberry Festival Kidz Zone, give free Narcan training, and hear about most things happening in town first. If you want to know what is going on in Ellenville, just call Matthews.
From our Google reviews
What neighbors say.
“I have been in Ellenville for 4 years, and the service and the way the staff there are top tier!! Have never had any problems always leave with a smile.”
“Outstanding service! The pharmacists and all the staff there are warm friendly helpful and always professional. I am grateful for this business.”
“Always helpful with drug information. A pleasure to shop & pick up your RXS. Staff professional at all times!”
Hours
| Monday | 9:00 AM – 6:00 PM |
|---|---|
| Tuesday | 9:00 AM – 6:00 PM |
| Wednesday | 9:00 AM – 6:00 PM |
| Thursday | 9:00 AM – 6:00 PM |
| Friday | 9:00 AM – 6:00 PM |
| Saturday | 9:00 AM – 3:00 PM |
| Sunday | Closed |
How do I transfer a prescription to Matthews Pharmacy?
Call us at (845) 647-6222. It takes one phone call; we handle the paperwork with your old pharmacy.
How do I refill a prescription?
Use our refill and patient portal online, or call (845) 647-6222.
What are your hours?
Monday to Friday 9:00 AM – 6:00 PM, Saturday 9:00 AM – 3:00 PM, closed Sunday.
Where are you located?
Do I need an appointment for a vaccine?
No. Walk in for flu, COVID-19, RSV, pneumonia, shingles or Tdap. No doctor’s office visit needed.

